Immunohistochemical expression of PDL1 in laryngeal carcinoma in relation to P53 and ki67 proliferative index

Squamous cell carcinoma of larynx is one the most common malignant neoplasms head and neck. Carcinoma represents 2.2% all cancers in men 0.4% women, with predilection old aged more than 50 years rather women. Smoking main risk factor. Alcohol, nutritional factors virus as Human papillomavirus (HPV) play a role pathogenesis laryngeal carcinoma. Programmed death-ligand (PDL1) new introduced marker that be considered treatment target nowadays addition to its prognostic application. Aims study: This study was designed assess predictive PDL1 squamous comparison other markers (P53 Ki-67). Results: The current revealed expression reported about 20 % 10% premalignant, while it negative benign lesions. Others markers; P53 protein shown positive around 42.5 percent carcinomas, 40 premalignant lesions, 12